Metagenomic analysis of the human distal gut microbiome.
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ABSTRACT:
SUBMITTER: Gill SR
PROVIDER: S-EPMC3027896 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
Metagenomic analysis of the human distal gut microbiome.
Gill Steven R SR Pop Mihai M Deboy Robert T RT Eckburg Paul B PB Turnbaugh Peter J PJ Samuel Buck S BS Gordon Jeffrey I JI Relman David A DA Fraser-Liggett Claire M CM Nelson Karen E KE
Science (New York, N.Y.) 20060601 5778
The human intestinal microbiota is composed of 10(13) to 10(14) microorganisms whose collective genome ("microbiome") contains at least 100 times as many genes as our own genome. We analyzed approximately 78 million base pairs of unique DNA sequence and 2062 polymerase chain reaction-amplified 16S ribosomal DNA sequences obtained from the fecal DNAs of two healthy adults. Using metabolic function analyses of identified genes, we compared our human genome with the average content of previously se ...[more]
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