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ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering.


ABSTRACT: Porous monolithic inorganic/polymeric hybrid materials have been prepared via ring-opening metathesis copolymerization starting from a highly polar monomer, i.e., cis-5-cyclooctene-trans-1,2-diol and a 7-oxanorborn-2-ene-derived cross-linker in the presence of porogenic solvents and two types of inorganic nanoparticles (i.e., CaCO? and calcium hydroxyapatite, respectively) using the third-generation Grubbs initiator RuCl?(Py)?(IMesH?)(CHPh). The physico-chemical properties of the monolithic materials, such as pore size distribution and microhardness were studied with regard to the nanoparticle type and content. Moreover, the reinforced monoliths were tested for the possible use as scaffold materials in tissue engineering, by carrying out cell cultivation experiments with human adipose tissue-derived stromal cells.

SUBMITTER: Weichelt F 

PROVIDER: S-EPMC3028601 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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ROMP-Derived cyclooctene-based monolithic polymeric materials reinforced with inorganic nanoparticles for applications in tissue engineering.

Weichelt Franziska F   Lenz Solvig S   Tiede Stefanie S   Reinhardt Ingrid I   Frerich Bernhard B   Buchmeiser Michael R MR  

Beilstein journal of organic chemistry 20101217


Porous monolithic inorganic/polymeric hybrid materials have been prepared via ring-opening metathesis copolymerization starting from a highly polar monomer, i.e., cis-5-cyclooctene-trans-1,2-diol and a 7-oxanorborn-2-ene-derived cross-linker in the presence of porogenic solvents and two types of inorganic nanoparticles (i.e., CaCO₃ and calcium hydroxyapatite, respectively) using the third-generation Grubbs initiator RuCl₂(Py)₂(IMesH₂)(CHPh). The physico-chemical properties of the monolithic mate  ...[more]

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