Ontology highlight
ABSTRACT:
SUBMITTER: Dunaway CM
PROVIDER: S-EPMC3028625 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Dunaway Charlene M CM Hwang Yoonha Y Lindsley Craig W CW Cook Rebecca S RS Wu Jane Y JY Boothby Mark M Chen Jin J Brantley-Sieders Dana M DM
Molecular and cellular biology 20101206 3
Slit proteins induce cytoskeletal remodeling through interaction with roundabout (Robo) receptors, regulating migration of neurons and nonneuronal cells, including leukocytes, tumor cells, and endothelium. The role of Slit2 in vascular remodeling, however, remains controversial, with reports of both pro- and antiangiogenic activity. We report here that cooperation between Slit2 and ephrin-A1 regulates a balance between the pro- and antiangiogenic functions of Slit2. While Slit2 promotes angiogen ...[more]