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Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.

ABSTRACT: Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.

SUBMITTER: Schutzer SE

PROVIDER: S-EPMC3028687 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.

Schutzer Steven E SE Fraser-Liggett Claire M CM Casjens Sherwood R SR Qiu Wei-Gang WG Dunn John J JJ Mongodin Emmanuel F EF Luft Benjamin J BJ

Journal of bacteriology 20101008 4

Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of na ...[more]

PMID: 20935092

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