Ontology highlight
ABSTRACT:
SUBMITTER: Arakawa C
PROVIDER: S-EPMC3028782 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Arakawa Chisato C Kuratsu Masahiro M Furihata Kazuo K Hiratsuka Tomoshige T Itoh Nobuya N Seto Haruo H Dairi Tohru T
Antimicrobial agents and chemotherapy 20101122 2
We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H ...[more]