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Diversity of the early step of the futalosine pathway.


ABSTRACT: We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs.

SUBMITTER: Arakawa C 

PROVIDER: S-EPMC3028782 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Diversity of the early step of the futalosine pathway.

Arakawa Chisato C   Kuratsu Masahiro M   Furihata Kazuo K   Hiratsuka Tomoshige T   Itoh Nobuya N   Seto Haruo H   Dairi Tohru T  

Antimicrobial agents and chemotherapy 20101122 2


We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H  ...[more]

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