Ontology highlight
ABSTRACT:
SUBMITTER: Ravasi P
PROVIDER: S-EPMC3028783 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Ravasi Pablo P Limansky Adriana S AS Rodriguez Ramiro E RE Viale Alejandro M AM Mussi María A MA
Antimicrobial agents and chemotherapy 20101122 2
ISAba825, an insertion sequence found inactivating Acinetobacter baumannii carO, was tagged with a kanamycin (Kn) resistance cassette. ISAba825::Kn effectively transposed in A. baumannii, showing preference for short, AT-enriched target sequences, generating 6- to 9-bp target duplications. Additionally, we detected the presence of ISAba825 upstream of a plasmid-borne bla(OXA-58) gene, generating a hybrid promoter largely enhancing its expression and leading to carbapenem resistance. Overall, a r ...[more]