Seeing the portal in herpes simplex virus type 1 B capsids.
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ABSTRACT:
SUBMITTER: Rochat RH
PROVIDER: S-EPMC3028901 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Seeing the portal in herpes simplex virus type 1 B capsids.
Rochat R H RH Liu X X Murata K K Nagayama K K Rixon F J FJ Chiu W W
Journal of virology 20101124 4
Resolving the nonicosahedral components in large icosahedral viruses remains a technical challenge in structural virology. We have used the emerging technique of Zernike phase-contrast electron cryomicroscopy to enhance the image contrast of ice-embedded herpes simplex virus type 1 capsids. Image reconstruction enabled us to retrieve the structure of the unique portal vertex in the context of the icosahedral capsid and, for the first time, show the subunit organization of a portal in a virus inf ...[more]
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