Ontology highlight
ABSTRACT:
SUBMITTER: Baydyuk M
PROVIDER: S-EPMC3029684 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Baydyuk Maryna M Russell Theron T Liao Guey-Ying GY Zang Keling K An Juan Ji JJ Reichardt Louis French LF Xu Baoji B
Proceedings of the National Academy of Sciences of the United States of America 20110104 4
In the peripheral nervous system, target tissues control the final size of innervating neuronal populations by producing limited amounts of survival-promoting neurotrophic factors during development. However, it remains largely unknown if the same principle works to regulate the size of neuronal populations in the developing brain. Here we show that neurotrophin signaling mediated by the TrkB receptor controls striatal size by promoting the survival of developing medium-sized spiny neurons (MSNs ...[more]