Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea.

ABSTRACT:

Rationale

Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease. We hypothesized that patients with OSA and no cardiovascular disease have oxidant-related microcirculatory endothelial dysfunction.

Objectives

To evaluate the microcirculation in OSA.

Methods

This study included seven patients with OSA and seven age- and weight-matched control subjects (mean age, 38 yr; mean body mass index, 32.5 kg/m²). All participants were free of cardiovascular risk factors. Participants received measurement of brachial artery flow-mediated dilation and forearm subcutaneous biopsy. Patients underwent repeated tests 12 weeks after treatment. Microcirculatory endothelial cells were isolated, and immunohistochemistry staining for peroxynitrite in the microcirculation

SUBMITTER: Patt BT 

PROVIDER: S-EPMC3029939 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature