Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC3030253 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Kim Jinhee J Jonasch Eric E Alexander Angela A Short John D JD Cai Shengli S Wen Sijin S Tsavachidou Dimitra D Tamboli Pheroze P Czerniak Bogdan A BA Do Kim Anh KA Wu Kevin J KJ Marlow Laura A LA Wood Christopher G CG Copland John A JA Walker Cheryl Lyn CL
Clinical cancer research : an official journal of the American Association for Cancer Research 20090101 1
<h4>Purpose</h4>p27 localization and expression has prognostic and predictive value in cancer. Little is known regarding expression patterns of p27 in renal cell carcinoma (RCC) or how p27 participates in disease progression or response to therapy.<h4>Experimental design</h4>RCC-derived cell lines, primary tumors, and normal renal epithelial cells were analyzed for p27 expression, phosphorylation (T157 of the NLS), and subcellular localization. RCC-derived cell lines were treated with phosphatid ...[more]