Ontology highlight
ABSTRACT:
SUBMITTER: Wyatt D
PROVIDER: S-EPMC3030389 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Wyatt Debra D Malik Rohit R Vesecky Alissa C AC Marchese Adriano A
The Journal of biological chemistry 20101130 5
Nonvisual arrestins are regulated by direct post-translational modifications, such as phosphorylation, ubiquitination, and nitrosylation. However, whether arrestins are regulated by other post-translational modifications remains unknown. Here we show that nonvisual arrestins are modified by small ubiquitin-like modifier 1 (SUMO-1) upon activation of β(2)-adrenergic receptor (β(2)AR). Lysine residues 295 and 400 in arrestin-3 fall within canonical SUMO consensus sites, and mutagenic analysis reve ...[more]