Ontology highlight
ABSTRACT:
SUBMITTER: Freeman A
PROVIDER: S-EPMC3030698 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Freeman Amanda A Franciscovich Amy A Bowers Mallory M Sandstrom David J DJ Sanyal Subhabrata S
Molecular and cellular neurosciences 20101224 2
The calcium-regulated transcription factor NFAT is emerging as a key regulator of neuronal development and plasticity but precise cellular consequences of NFAT function remain poorly understood. Here, we report that the single Drosophila NFAT homolog is widely expressed in the nervous system including motor neurons and unexpectedly controls neural excitability. Likely due to this effect on excitability, NFAT regulates overall larval locomotion and both chronic and acute forms of activity-depende ...[more]