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Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33.

ABSTRACT: Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2-3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance.

SUBMITTER: Raza MH

PROVIDER: S-EPMC3030966 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Identification of an autosomal recessive stuttering locus on chromosome 3q13.2-3q13.33.

Raza Muhammad Hashim MH Riazuddin Sheikh S Drayna Dennis D

Human genetics 20100813 4

Stuttering is a common speech disorder with substantial genetic contributions. To better understand the genetic factors involved in stuttering, we performed a genome-wide linkage study in a newly-ascertained consanguineous stuttering family from Pakistan. A linkage scan in this family using parametric linkage analysis revealed significant linkage only on chromosome 3q13.2-3q13.33, with a maximum two-point LOD score of 4.23 under an autosomal recessive model of inheritance. ...[more]

PMID: 20706738

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