Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.
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ABSTRACT:
SUBMITTER: Cella M
PROVIDER: S-EPMC3031090 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.
Cella Marina M Presti Rachel R Vermi William W Lavender Kerry K Turnbull Emma E Ochsenbauer-Jambor Christina C Kappes John C JC Ferrari Guido G Kessels Lisa L Williams Ian I McMichael Andrew J AJ Haynes Barton F BF Borrow Persephone P Colonna Marco M
European journal of immunology 20100401 4
The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8(+) T cells that leads to persisting viral replication. It is generally believed that exhaustion is a consequence of the accumulation of multiple inhibitory receptors on CD8(+) T cells that makes them dysfunctional. Here, we show that during human chronic HIV-1 infection, a CD8(+) T-cell positive costimulatory pathway mediated by DNAX-activating molecule-1 is also disrupted. Thus, DNAX-activating molecule ...[more]
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