New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering.
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ABSTRACT:
SUBMITTER: McDonald DM
PROVIDER: S-EPMC3031147 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering.
Cancer cell 20101201 6
Tvorogov et al. (2010) describe in this issue of Cancer Cell an antibody that inhibits homodimerization of vascular endothelial growth factor receptor-3 (VEGFR-3) and its heterodimerization with VEGFR-2, but not ligand binding. The work provides mechanistic insights into receptor dimerization and an approach to suppress both angiogenesis and lymphangiogenesis. ...[more]
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