Ontology highlight
ABSTRACT:
SUBMITTER: Chmelar J
PROVIDER: S-EPMC3031492 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Chmelar Jindrich J Oliveira Carlo J CJ Rezacova Pavlina P Francischetti Ivo M B IM Kovarova Zuzana Z Pejler Gunnar G Kopacek Peter P Ribeiro José M C JM Mares Michael M Kopecky Jan J Kotsyfakis Michail M
Blood 20101012 2
Platelet aggregation and acute inflammation are key processes in vertebrate defense to a skin injury. Recent studies uncovered the mediation of 2 serine proteases, cathepsin G and chymase, in both mechanisms. Working with a mouse model of acute inflammation, we revealed that an exogenous salivary protein of Ixodes ricinus, the vector of Lyme disease pathogens in Europe, extensively inhibits edema formation and influx of neutrophils in the inflamed tissue. We named this tick salivary gland secret ...[more]