Ontology highlight
ABSTRACT:
SUBMITTER: Ott CE
PROVIDER: S-EPMC3031556 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Ott Claus Eric CE Grünhagen Johannes J Jäger Marten M Horbelt Daniel D Schwill Simon S Kallenbach Klaus K Guo Gao G Manke Thomas T Knaus Petra P Mundlos Stefan S Robinson Peter N PN
PloS one 20110131 1
Elastin production is characteristically turned off during the maturation of elastin-rich organs such as the aorta. MicroRNAs (miRNAs) are small regulatory RNAs that down-regulate target mRNAs by binding to miRNA regulatory elements (MREs) typically located in the 3' UTR. Here we show a striking up-regulation of miR-29 and miR-15 family miRNAs during murine aortic development with commensurate down-regulation of targets including elastin and other extracellular matrix (ECM) genes. There were a t ...[more]