Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3031727 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Liu Yan Y Zhang Zhikai Z Jiang Yongquan Y Zhang Lihong L Popov Vsevolod L VL Zhang Jianzhi J Walker David H DH Yu Xue-jie XJ
Microbes and infection 20101109 3
Ehrlichia are obligately intracellular bacteria that reside in a vacuole in the cytoplasm of phagocytes. We determined by confocal microscopy the interaction between Ehrlichia and mitochondria in DH82 cells to investigate the mechanism of Ehrlichia survival inside the phagocyte. The most remarkable finding of our study was that Ehrlichia morulae interacted with mitochondria and inhibited mitochondrial metabolism. We showed that in Ehrlichia chaffeensis-infected DH82 cells, mitochondria did not i ...[more]