Ontology highlight
ABSTRACT:
SUBMITTER: Duteil D
PROVIDER: S-EPMC3032428 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Duteil Delphine D Chambon Céline C Ali Faisal F Malivindi Rocco R Zoll Joffrey J Kato Shigeaki S Geny Bernard B Chambon Pierre P Metzger Daniel D
Cell metabolism 20101101 5
The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver. To analyze TIF2 cell-autonomous functions in skeletal muscles, we generated TIF2((i)skm)⁻(/)⁻ mice in which TIF2 was selectively ablated in skeletal muscle myofibers at adulthood. We found that increased mitochondrial uncoupling in skeletal muscle myocytes protected these mice from decreased muscle oxidative capacities induced by se ...[more]