Ontology highlight
ABSTRACT:
SUBMITTER: Wirawan E
PROVIDER: S-EPMC3032505 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Wirawan E E Vande Walle L L Kersse K K Cornelis S S Claerhout S S Vanoverberghe I I Roelandt R R De Rycke R R Verspurten J J Declercq W W Agostinis P P Vanden Berghe T T Lippens S S Vandenabeele P P
Cell death & disease 20100101
Autophagy and apoptosis are two important and interconnected stress-response mechanisms. However, the molecular interplay between these two pathways is not fully understood. To study the fate and function of autophagic proteins at the onset of apoptosis, we used a cellular model system in which autophagy precedes apoptosis. IL-3 depletion of Ba/F3 cells caused caspase (casp)-mediated cleavage of Beclin-1 and PI3KC3, two crucial components of the autophagy-inducing complex. We identified two casp ...[more]