Ontology highlight
ABSTRACT:
SUBMITTER: Straub WE
PROVIDER: S-EPMC3032508 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Straub W E WE Weber T A TA Schäfer B B Candi E E Durst F F Ou H D HD Rajalingam K K Melino G G Dötsch V V
Cell death & disease 20100101
The transcription factor p63 is expressed as at least six different isoforms, of which two have been assigned critical biological roles within ectodermal development and skin stem cell biology on the one hand and supervision of the genetic stability of oocytes on the other hand. These two isoforms contain a C-terminal inhibitory domain that negatively regulates their transcriptional activity. This inhibitory domain contains two individual components: one that uses an internal binding mechanism t ...[more]