Ontology highlight
ABSTRACT:
SUBMITTER: Gao L
PROVIDER: S-EPMC3032959 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Gao Lin L Li Hong H Li Kai K Shen Zhu Z Liu Ling L Li Chunying C Zhang Zhengdong Z Liu Yufeng Y
Genetics and molecular biology 20090110 1
PSORIASIS VULGARIS IS DEFINED BY A SERIES OF LINKED CELLULAR CHANGES IN THE SKIN: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils and other types of leukocytes in the affected skin. Catechol-O-methyltransferase (COMT) 158 polymorphism can reduce the activity of the COMT enzyme that may trigger defective differentiation of keratinocytes in psoriasis. Immunocytes can degrade and inactivate catecholamines via monamine oxidase ...[more]