Ontology highlight
ABSTRACT:
SUBMITTER: Wright E
PROVIDER: S-EPMC3032979 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Wright Edward E Busby Scott A SA Wisecarver Sarah S Vincent Jeremy J Griffin Patrick R PR Fernandez Elias J EJ
Structure (London, England : 1993) 20110101 1
The constitutive androstane receptor (CAR) transactivation can occur in the absence of exogenous ligand and this activity is enhanced by agonists TCPOBOP and meclizine. We use biophysical and cell-based assays to show that increased activity of CAR(TCPOBOP) relative to CAR(meclizine) corresponds to a higher affinity of CAR(TCPOBOP) for the steroid receptor coactivator-1. Additionally, steady-state fluorescence spectra suggest conformational differences between CAR(TCPOBOP):RXR and CAR(meclizine) ...[more]