Ontology highlight
ABSTRACT:
SUBMITTER: Toll L
PROVIDER: S-EPMC3033720 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Toll L L Jimenez L L Waleh N N Jozwiak K K Woo A Y-H AY Xiao R-P RP Bernier M M Wainer I W IW
The Journal of pharmacology and experimental therapeutics 20101111 2
Astrocytomas and glioblastomas have been particularly difficult to treat and refractory to chemotherapy. However, significant evidence has been presented that demonstrates a decrease in astrocytoma cell proliferation subsequent to an increase in cAMP levels. The 1321N1 astrocytoma cell line, as well as other astrocytomas and glioblastomas, expresses β(2)-adrenergic receptors (β(2)-ARs) that are coupled to G(s) activation and consequent cAMP production. Experiments were conducted to determine whe ...[more]