Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads.
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ABSTRACT:
SUBMITTER: Gu L
PROVIDER: S-EPMC3033739 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads.
Gu Luo L Park Ji-Ho JH Duong Kim H KH Ruoslahti Erkki E Sailor Michael J MJ
Small (Weinheim an der Bergstrasse, Germany) 20101101 22
Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid-containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with superparamagnetic ...[more]
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