Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.
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ABSTRACT:
SUBMITTER: Chen SH
PROVIDER: S-EPMC303395 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Publications
Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.
Chen Shih-Heng SH Pearson Angela A Coen Donald M DM Chen Shun-Hua SH
Journal of virology 20040101 1
Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate. ...[more]
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