Ontology highlight
ABSTRACT:
SUBMITTER: Cosentino C
PROVIDER: S-EPMC3034007 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Cosentino Claudia C Grieco Domenico D Costanzo Vincenzo V
The EMBO journal 20101214 3
Ataxia telangiectasia (A-T) is a human disease caused by ATM deficiency characterized among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and neurological defects. ATM controls several aspects of cell cycle and promotes repair of double strand breaks (DSBs). This probably accounts for most of A-T clinical manifestations. However, an impaired response to reactive oxygen species (ROS) might also contribute to A-T pathogenesis. Here, we show that ATM promotes an anti-oxida ...[more]