Ontology highlight
ABSTRACT:
SUBMITTER: Laursen NS
PROVIDER: S-EPMC3034014 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Laursen Nick S NS Andersen Kasper R KR Braren Ingke I Spillner Edzard E Sottrup-Jensen Lars L Andersen Gregers R GR
The EMBO journal 20110107 3
Complement acts as a danger-sensing system in the innate immune system, and its activation initiates a strong inflammatory response and cleavage of the proteins C3 and C5 by proteolytic enzymes, the convertases. These contain a non-catalytic substrate contacting subunit (C3b or C4b) in complex with a protease subunit (Bb or C2a). We determined the crystal structures of the C3b homologue cobra venom factor (CVF) in complex with C5, and in complex with C5 and the inhibitor SSL7 at 4.3 Å resolution ...[more]