Ontology highlight
ABSTRACT:
SUBMITTER: Trunkfield AE
PROVIDER: S-EPMC3034214 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20100219 7
Glycosyltransferase MurG catalyses the transfer of N-acetyl-d-glucosamine to lipid intermediate I on the bacterial peptidoglycan biosynthesis pathway, and is a target for development of new antibacterial agents. A transition state mimic was designed for MurG, containing a functionalised proline, linked through the alpha-carboxylic acid, via a spacer, to a uridine nucleoside. A set of 15 functionalised prolines were synthesised, using a convergent dipolar cycloaddition reaction, which were couple ...[more]