Ontology highlight
ABSTRACT:
SUBMITTER: Scott LM
PROVIDER: S-EPMC3034307 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Scott Latanya M LM Chen Liwei L Daniel Kenyon G KG Brooks Wesley H WH Guida Wayne C WC Lawrence Harshani R HR Sebti Said M SM Lawrence Nicholas J NJ Wu Jie J
Bioorganic & medicinal chemistry letters 20101204 2
Shp2 protein tyrosine phosphate (PTP) is a novel target for anticancer drug discovery. We identified estramustine phosphate as a Shp2 PTP inhibitor from the National Cancer Institute Approved Oncology Drug set. A focused structure-activity relationship study indicated that the 17-phosphate group is required for the Shp2 PTP inhibitor activity of estramustine phosphate. A search for estramustine phosphate analogs led to identification of two triterpenoids, enoxolone, and celastrol, having Shp2 PT ...[more]