Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3034605 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Liu Ying Y Gao Zeng Qiang ZQ Liu Chao Pei CP Xu Jian Hua JH Li Lan Fen LF Ji Chao Neng CN Su Xiao Dong XD Dong Yu Hui YH
Acta crystallographica. Section F, Structural biology and crystallization communications 20110121 Pt 2
Streptococcus mutans is one of the pathogenic species involved in dental caries, especially in the initiation and development stages. Here, the crystal structure of SMU.595, a putative dihydroorotate dehydrogenase (DHOD) from S. mutans, is reported at 2.4 Å resolution. DHOD is a flavin mononucleotide-containing enzyme which catalyzes the oxidation of L-dihydroorotate to orotate, which is the fourth step and the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. The reduct ...[more]