Ontology highlight
ABSTRACT:
SUBMITTER: Brunstein CG
PROVIDER: S-EPMC3035067 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Brunstein Claudio G CG Miller Jeffrey S JS Cao Qing Q McKenna David H DH Hippen Keli L KL Curtsinger Julie J Defor Todd T Levine Bruce L BL June Carl H CH Rubinstein Pablo P McGlave Philip B PB Blazar Bruce R BR Wagner John E JE
Blood 20101015 3
Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and mortality and is a common complication after double umbilical cord blood (UCB) transplantation. To reduce these risks, we established a method of CD4(+)CD25(+)FoxP3(+) T regulatory cell (Treg) enrichment from cryopreserved UCB followed by a 18 (+) 1-day expansion culture including anti-CD3/anti-CD28 antibody-coated beads and recombinant human interleukin-2. In a "first-in-human" clinical trial, we evaluated the ...[more]