Ontology highlight
ABSTRACT:
SUBMITTER: Nostro MC
PROVIDER: S-EPMC3035090 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20110126 5
The generation of insulin-producing β-cells from human pluripotent stem cells is dependent on efficient endoderm induction and appropriate patterning and specification of this germ layer to a pancreatic fate. In this study, we elucidated the temporal requirements for TGFβ family members and canonical WNT signaling at these developmental stages and show that the duration of nodal/activin A signaling plays a pivotal role in establishing an appropriate definitive endoderm population for specificati ...[more]