Ontology highlight
ABSTRACT:
SUBMITTER: Leyva MJ
PROVIDER: S-EPMC3035168 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Leyva Melissa J MJ Degiacomo Francesco F Kaltenbach Linda S LS Holcomb Jennifer J Zhang Ningzhe N Gafni Juliette J Park Hyunsun H Lo Donald C DC Salvesen Guy S GS Ellerby Lisa M LM Ellman Jonathan A JA
Chemistry & biology 20101101 11
Huntington's Disease (HD) is characterized by a mutation in the huntingtin (Htt) gene encoding an expansion of glutamine repeats on the N terminus of the Htt protein. Numerous studies have identified Htt proteolysis as a critical pathological event in HD postmortem human tissue and mouse HD models, and proteases known as caspases have emerged as attractive HD therapeutic targets. We report the use of the substrate activity screening method against caspase-3 and -6 to identify three novel, pan-ca ...[more]