Ontology highlight
ABSTRACT:
SUBMITTER: Lin FY
PROVIDER: S-EPMC3035457 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Lin Fang-Yu FY Chang Ching-Wen CW Cheong Mei-Leng ML Chen Hsei-Chorn HC Lee Der-Yen DY Chang Geen-Dong GD Chen Hungwen H
Nucleic acids research 20100919 3
Glial cells missing homolog 1 (GCM1) is a transcription factor essential for placental development. GCM1 promotes syncytiotrophoblast formation and placental vasculogenesis by activating fusogenic and proangiogenic gene expression in placenta. GCM1 activity is regulated by multiple post-translational modifications. The cAMP/PKA-signaling pathway promotes CBP-mediated GCM1 acetylation and stabilizes GCM1, whereas hypoxia-induced GSK-3β-mediated phosphorylation of Ser322 causes GCM1 ubiquitination ...[more]