Ontology highlight
ABSTRACT:
SUBMITTER: Lin SL
PROVIDER: S-EPMC3035461 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Lin Shi-Lung SL Chang Donald C DC Lin Chun-Hung CH Ying Shao-Yao SY Leu Davey D Wu David T S DT
Nucleic acids research 20100924 3
Global demethylation is required for early zygote development to establish stem cell pluripotency, yet our findings reiterate this epigenetic reprogramming event in somatic cells through ectopic introduction of mir-302 function. Here, we report that induced mir-302 expression beyond 1.3-fold of the concentration in human embryonic stem (hES) H1 and H9 cells led to reprogramming of human hair follicle cells (hHFCs) to induced pluripotent stem (iPS) cells. This reprogramming mechanism functioned t ...[more]