Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto J
PROVIDER: S-EPMC3035463 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Yamamoto Junpei J Nishiguchi Kosuke K Manabe Koichiro K Masutani Chikahide C Hanaoka Fumio F Iwai Shigenori S
Nucleic acids research 20100929 3
Photocycloaddition between two adjacent bases in DNA produces a cyclobutane pyrimidine dimer (CPD), which is one of the major UV-induced DNA lesions, with either the cis-syn or trans-syn structure. In this study, we investigated the photosensitized intramolecular cycloaddition of partially-protected thymidylyl-(3'→5')-N(4)-acetyl-2'-deoxy-5-methylcytidine, to clarify the effect of the base modification on the cycloaddition reaction. The reaction resulted in the stereoselective formation of the t ...[more]