Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.
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ABSTRACT:
SUBMITTER: Shulman JM
PROVIDER: S-EPMC3035702 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Functional screening of Alzheimer pathology genome-wide association signals in Drosophila.
Shulman Joshua M JM Chipendo Portia P Chibnik Lori B LB Aubin Cristin C Tran Dong D Keenan Brendan T BT Kramer Patricia L PL Schneider Julie A JA Bennett David A DA Feany Mel B MB De Jager Philip L PL
American journal of human genetics 20110203 2
We have leveraged a Drosophila model relevant to Alzheimer disease (AD) for functional screening of findings from a genome-wide scan for loci associated with a quantitative measure of AD pathology in humans. In six of the 15 genomic regions evaluated, we successfully identified a causal gene for the association, on the basis of in vivo interactions with the neurotoxicity of Tau, which forms neurofibrillary tangles in AD. Among the top results, rs10845990 within SLC2A14, encoding a glucose transp ...[more]
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