CTLA4CT60 gene polymorphism is not associated with differential susceptibility to pemphigus foliaceus.
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ABSTRACT:
SUBMITTER: Pincerati MR
PROVIDER: S-EPMC3036102 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
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CTLA4CT60 gene polymorphism is not associated with differential susceptibility to pemphigus foliaceus.
Pincerati Márcia Regina MR Dalla-Costa Ricardo R Petzl-Erler Maria Luiza ML
Genetics and molecular biology 20100701 3
Pemphigus foliaceus is an organ-specific autoimmune disease characterized by autoantibodies against the extracellular region of desmoglein 1, a protein that mediates intercellular adhesion in desmosomes. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a key negative regulator of the T cell immune response, playing an important role in T cell homeostasis and maintenance of peripheral tolerance. Polymorphisms in the CTLA4 gene have been associated with autoimmune diseases and the functiona ...[more]
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