Interactions of polymorphisms in different clock genes associated with circadian phenotypes in humans.

ABSTRACT: Several studies have shown that mutations and polymorphisms in clock genes are associated with abnormal circadian parameters in humans and also with more subtle non-pathological phenotypes like chronotypes. However, there have been conflicting results, and none of these studies analyzed the combined effects of more than one clock gene. Up to date, association studies in humans have focused on the analysis of only one clock gene per study. Since these genes encode proteins that physically interact with each other, combinations of polymorphisms in different clock genes could have a synergistic or an inhibitory effect upon circadian phenotypes. In the present study, we analyzed the combined effects of four polymorphisms in four clock genes (Per2, Per3, Clock and Bmal1) in people with extreme

SUBMITTER: Pedrazzoli M 

PROVIDER: S-EPMC3036144 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature