Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian HK
PROVIDER: S-EPMC3036790 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Subramanian Hari K K HK Chakraborty Banani B Sha Ruojie R Seeman Nadrian C NC
Nano letters 20110114 2
Single nucleotide polymorphisms (SNPs) are the most common genetic variation in the human genome. Kinetic methods based on branch migration have proved successful for detecting SNPs because a mispair inhibits the progress of branch migration in the direction of the mispair. We have combined the effectiveness of kinetic methods with atomic force microscopy of DNA origami patterns to produce a direct visual readout of the target nucleotide contained in the probe sequence. The origami contains grap ...[more]