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Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease.


ABSTRACT: We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying the AA genotype was reduced by 83% in relation to individuals carrying the G/G genotype (OR = 0.172, 95% CI: 0.057-0.526, p = 0.002). Our results indicate that -463G > A polymorphism of the myeloperoxidase gene is associated with premature CAD in Chinese individuals, suggesting that the AA genotype is a protective factor against premature CAD.

SUBMITTER: Zhong C 

PROVIDER: S-EPMC3036926 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Myeloperoxidase gene-463G > A polymorphism and premature coronary artery disease.

Zhong Chen C   Quanzhong Yin Y   Genshan Ma M   Hua Zhang Z   Ruolong Zheng Z   Jiahong Wang W   Chunheng Gao G  

Genetics and molecular biology 20090401 2


We investigated the association between myeloperoxidase gene -463G > A polymorphism and premature coronary artery disease (CAD) in two Chinese population samples: 229 patients and 230 controls. Genotypes were determined by ligase detection reaction-polymerase chain reaction sequencing and the grouping technique. We found lower frequencies of both the A/A genotype and the A allele in patients (p < 0.05). Multivariate logistic regression showed that the risk of premature CAD in subjects carrying t  ...[more]

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