Ontology highlight
ABSTRACT:
SUBMITTER: Guimaraes AJ
PROVIDER: S-EPMC3037374 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Guimarães Allan Jefferson AJ Nakayasu Ernesto S ES Sobreira Tiago J P TJ Cordero Radames J B RJ Nimrichter Leonardo L Almeida Igor C IC Nosanchuk Joshua Daniel JD
PloS one 20110210 2
Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins. Hsps are essential regulators of diverse constitutive metabolic processes and are markedly upregulated during stress. A 62 kDa Hsp (Hsp60) of Histoplasma capsulatum (Hc) is an immunodominant antigen and the major surface ligand to CR3 receptors on macrophages. However little is known about the function of this protein within the fungus. We characterized Hc Hsp60-protein interactions under differ ...[more]