Ontology highlight
ABSTRACT:
SUBMITTER: Monypenny J
PROVIDER: S-EPMC3037472 | biostudies-literature | 2011 Feb-Mar
REPOSITORIES: biostudies-literature
Monypenny James J Chou Hsiu-Chuan HC Bañón-Rodríguez Inmaculada I Thrasher Adrian J AJ Antón Inés M IM Jones Gareth E GE Calle Yolanda Y
European journal of cell biology 20100706 2-3
The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polarised myeloid cells including dendritic cells, macrophages and osteoclasts develop podosomes that sustain the extending leading edge. Podosome integrity and dynamics vary in response to changes in the physical and biochemical properties of the cell environment. In the current arti ...[more]