Ontology highlight
ABSTRACT:
SUBMITTER: Mokrab Y
PROVIDER: S-EPMC3037555 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Mokrab Younes Y Sansom Mark S P MS
Biophysical journal 20110201 4
Voltage sensors (VS) domains couple the activation of ion channels/enzymes to changes in membrane voltage. We used molecular dynamics simulations to examine interactions with lipids of several VS homologs. VSs in intact channels in the activated state are exposed to phospholipids, leading to a characteristic local distortion of the lipid bilayer which decreases its thickness by ∼10 Å. This effect is mediated by a conserved hydrophilic stretch in the S4-S5 segment linking the VS and the pore doma ...[more]