Ontology highlight
ABSTRACT:
SUBMITTER: Kappel C
PROVIDER: S-EPMC3037603 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Kappel Christian C Grubmüller Helmut H
Biophysical journal 20110201 4
Bacteriorhodopsin is a model system for membrane proteins. This seven transmembrane helical protein is embedded within a membrane structure called purple membrane. Its structural stability against mechanical stress was recently investigated by atomic force microscopy experiments, in which single proteins were extracted from the purple membrane. Here, we study this process by all-atom molecular dynamics simulations, in which single bacteriorhodopsin molecules were extracted and unfolded from an a ...[more]