Ontology highlight
ABSTRACT:
SUBMITTER: Polanska UM
PROVIDER: S-EPMC3037679 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20101221 7
FGFs have traditionally been associated with cell proliferation, morphogenesis, and development; yet, a subfamily of FGFs (FGF19, -21, and -23) functions as hormones to regulate glucose, lipid, phosphate, and vitamin D metabolism with impact on energy balance and aging. In mammals, Klotho and beta-Klotho are type 1 transmembrane proteins that function as obligatory co-factors for endocrine FGFs to bind to their cognate FGF receptors (FGFRs). Mutations in Klotho/beta-Klotho or fgf19, -21, or -23 ...[more]