Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC3037905 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Liu Hongde H Duan Xueye X Yu Shuangxin S Sun Xiao X
BMC genomics 20110127
<h4>Background</h4>Nucleosome positioning has an important role in gene regulation. However, dynamic positioning in vivo casts doubt on the reliability of predictions based on DNA sequence characteristics. What role does sequence-dependent positioning play? In this paper, using a curvature profile model, nucleosomes are predicted in the human genome and patterns of nucleosomes near some key sites are investigated.<h4>Results</h4>Curvature profiling revealed that in the vicinity of a transcriptio ...[more]