Ontology highlight
ABSTRACT:
SUBMITTER: Holstein SA
PROVIDER: S-EPMC3038195 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Holstein Sarah A SA Hohl Raymond J RJ
Leukemia research 20100909 4
Myeloma is characterized by the overproduction and secretion of monoclonal protein. Inhibitors of the isoprenoid biosynthetic pathway (IBP) have pleiotropic effects in myeloma cells. To investigate whether IBP inhibition interferes with monoclonal protein secretion, human myeloma cells were treated with specific inhibitors of the IBP or prenyltransferases. These studies demonstrate that agents that inhibit Rab geranylgeranylation disrupt light chain trafficking, lead to accumulation of light cha ...[more]