Ontology highlight
ABSTRACT:
SUBMITTER: Kuhn S
PROVIDER: S-EPMC3038748 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Kuhn Stephanie S Johnson Stuart L SL Furness David N DN Chen Jing J Ingham Neil N Hilton Jennifer M JM Steffes Georg G Lewis Morag A MA Zampini Valeria V Hackney Carole M CM Masetto Sergio S Holley Matthew C MC Steel Karen P KP Marcotti Walter W
Proceedings of the National Academy of Sciences of the United States of America 20110118 6
MicroRNAs (miRNAs) are small noncoding RNAs able to regulate a broad range of protein-coding genes involved in many biological processes. miR-96 is a sensory organ-specific miRNA expressed in the mammalian cochlea during development. Mutations in miR-96 cause nonsyndromic progressive hearing loss in humans and mice. The mouse mutant diminuendo has a single base change in the seed region of the Mir96 gene leading to widespread changes in the expression of many genes. We have used this mutant to e ...[more]